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IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs. MILK THISTLE (Silybum marianum) - ORAL USES: Milk thistle has been used for diabetes in combination with standard treatment. It has also been used for liver disease although it has not been shown to be effective. Consult your doctor for more information if you have either of these serious conditions. Some herbal/dietary supplement products have been found to contain possibly harmful impurities/additives. Check with your pharmacist for more details about the brand you use. The FDA has not reviewed this product for safety or effectiveness. Consult your doctor or pharmacist for more details. HOW TO USE: Take this product by mouth as directed. Follow all directions on the product package. If you are uncertain about any of the information, consult your doctor or pharmacist. If your condition persists or worsens, or if you think you may have a serious medical problem, seek immediate medical attention. SIDE EFFECTS: Loose stools or upset stomach may occur. If any of these effects persist or worsen, contact your doctor or pharmacist promptly. A very serious allergic reaction to this product is rare. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. PRECAUTIONS: Before taking milk thistle, tell your doctor or pharmacist if you are allergic to it; or to ragweed, chrysanthemums, marigolds, or daisies; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. If you have any of the following health problems, consult your doctor or pharmacist before using this product: conditions that are affected by estrogen (e.g., endometriosis, uterine fibroids, cancer of the breast/uterus/ovary). Liquid forms of this product may contain sugar and/or alcohol. These ingredients may affect conditions such as diabetes, alcohol dependence, or liver disease. Ask your doctor or pharmacist about using this product safely. This product is not recommended for use during pregnancy. Consult your doctor before using this product. It is unknown if this product passes into breast milk. Consult your doctor before breast-feeding. DRUG INTERACTIONS: Before using this product, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: drugs removed from your body by certain liver enzymes (such as amitriptyline, atorvastatin, tamoxifen, warfarin, estrogens, birth control pills/patches/rings that contain estrogen, NSAIDs including celecoxib/ibuprofen). Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first. This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. NOTES: Keep all regular medical and laboratory appointments. MISSED DOSE: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up. STORAGE: Refer to storage information printed on the package. If you have any questions about storage, ask your pharmacist. Keep all medications and herbal products away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product. Information last revised June 2018. Copyright(c) 2018 First Databank, Inc.